uvrC gene function has no specific role in repair of N-2-aminofluorene adducts
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چکیده
منابع مشابه
N-2-Aminofluorene Adducts
The Escherichia coli UvrABC endonuclease is known to be involved in the repair of DNA damage induced by UV irradiation (6, 11, 23, 25) or a large number of chemical agents (1, 10, 12, 19, 24). This enzyme, termed excinuclease (12, 19), is constituted by three subunits. UvrA binds weakly to DNA in an ATP-dependent manner, UvrB binds to UvrA and DNA to form a stable complex which scans the DNA (1...
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Nucleotide excision repair plays a crucial role in removing many types of DNA adducts formed by UV light and chemical carcinogens. We have examined the interactions of Escherichia coli UvrABC nuclease proteins with three site-specific C8 guanine adducts formed by the carcinogens 2-aminofluorene (AF), N:-acetyl-2-acetylaminofluorene (AAF) and 1-nitropyrene (1-NP) in a 50mer oligonucleotide. Simi...
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ژورنال
عنوان ژورنال: Journal of Bacteriology
سال: 1987
ISSN: 0021-9193,1098-5530
DOI: 10.1128/jb.169.1.423-426.1987